Exosome-Mediated Metastasis: From Epithelial-Mesenchymal Transition to Escape from Immunosurveillance

Recently, researchers from Cancer Science Institute, National University of Singapore published a review in the Cell Press journal, Trends in Pharmacological Sciences, on the role of exosomes in facilitating and promoting tumour metastasis.

The first author, Nicholas Syn, works on cancer and metastatis. The review talks about how targeting tumour-derived exosomes dysregulation pathways, such as the heparanase/syndecan-1 axis, could represent novel therapeutic strategies in the quest to conquer cancer.

In this review, the authors have elaborated a conceptual framework for exosome-mediated metastasis and potential pharmacological strategies against it.

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Categories: Asia, Cancer, NUS, Research, Singapore

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