Karima Djabali’s group from Technische Universität Münche (TUM), Germany and other scientists from USA have found out that Sulforaphane, found in young broccoli sprouts, enhances the clearance of progerin in Hutchinson-Gilford progeria syndrome (HGPS). HGPS is a rare disorder characterized by premature aging with rapid growth deceleration in childhood and is due to a point mutation in the lamin A gene resulting in a truncated protein called progerin. Their study suggests that consumption of broccoli would increase the intake of Sulforaphane, a potent inducer of anti-oxidant enzymes. These enzymes would reduce the oxidative stress, which is enhanced in HGPS. Also, Sulforaphane enhanced the protein degradation of progerin, reduced the levels of DNA damage and improved the nuclear morphology of HGPS fibroblasts. The results of this study were published on 16th December 2014 in the leading journal, Aging cell.
The original article can be read at: http://onlinelibrary.wiley.com/doi/10.1111/acel.12300/full